Environmental and genetic risk factors in Parkinson's disease: A case–control study in southern italy
Identifieur interne : 002179 ( Main/Exploration ); précédent : 002178; suivant : 002180Environmental and genetic risk factors in Parkinson's disease: A case–control study in southern italy
Auteurs : G. De Michele ; A. Filla ; G. Volpe ; V. De Marco ; A. Gogliettino ; G. Ambrosio ; R. Marconi [Italie] ; A. E. Castellano [Italie] ; CampanellaSource :
- Movement Disorders [ 0885-3185 ] ; 1996-01.
English descriptors
Abstract
To clarify the role of heredity and of some environmental risk factors in the etiology of idopathic Parkinson's disease, we performed a case‐control study in two regions of southern Italy, Campania and Molise. We selected two controls for each parkinsonian patient, the patient's spouse and a sex‐ and age‐matched neurological control. One hundred sixteen consecutive outpatients with Parkinson's disease (77 men, 39 women; mean age ± SD = 62.5 ± 9.9) and the same number of spouses and neurological controls were interviewed about five environmental risk factors (cigarette smoking, well‐water drinking, head trauma with loss of consciousness, strict diets, general anesthesia) and two genetic risk factors (family history of Parkinson's disease or of essential tremor). Well‐water drinking and family history of Parkinson's disease or essential tremor showed a positive association with Parkinson's disease; smoking showed a negative association. The most relevant risk factor was history of familial Parkinson's disease (odds ratio = 14.6; 95% confidence interval = 7.2 − 29.6); 33% of our patients had at least one affected relative. We also showed a unilateral distribution of ancestral secondary cases on the paternal or on the maternal side, which suggests a dominant inheritance. Clinical and epidemiologic features of cases with familial Parkinson's disease showed no peculiarity. The study suggests a strong role of the genetic factors in the etiology of Parkinson's disease.
Url:
DOI: 10.1002/mds.870110105
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Environmental and genetic risk factors in Parkinson's disease: A case–control study in southern italy</title>
<author><name sortKey="De Michele, G" sort="De Michele, G" uniqKey="De Michele G" first="G." last="De Michele">G. De Michele</name>
</author>
<author><name sortKey="Filla, A" sort="Filla, A" uniqKey="Filla A" first="A." last="Filla">A. Filla</name>
</author>
<author><name sortKey="Volpe, G" sort="Volpe, G" uniqKey="Volpe G" first="G." last="Volpe">G. Volpe</name>
</author>
<author><name sortKey="De Marco, V" sort="De Marco, V" uniqKey="De Marco V" first="V." last="De Marco">V. De Marco</name>
</author>
<author><name sortKey="Gogliettino, A" sort="Gogliettino, A" uniqKey="Gogliettino A" first="A." last="Gogliettino">A. Gogliettino</name>
</author>
<author><name sortKey="Ambrosio, G" sort="Ambrosio, G" uniqKey="Ambrosio G" first="G." last="Ambrosio">G. Ambrosio</name>
</author>
<author><name sortKey="Marconi, R" sort="Marconi, R" uniqKey="Marconi R" first="R." last="Marconi">R. Marconi</name>
</author>
<author><name sortKey="Castellano, A E" sort="Castellano, A E" uniqKey="Castellano A" first="A. E." last="Castellano">A. E. Castellano</name>
</author>
<author><name sortKey="Campanella" sort="Campanella" uniqKey="Campanella" last="Campanella">Campanella</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:F7568060A721FF11CB5A29DD33B94F440BE1CB16</idno>
<date when="1996" year="1996">1996</date>
<idno type="doi">10.1002/mds.870110105</idno>
<idno type="url">https://api.istex.fr/document/F7568060A721FF11CB5A29DD33B94F440BE1CB16/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">002975</idno>
<idno type="wicri:Area/Main/Curation">002622</idno>
<idno type="wicri:Area/Main/Exploration">002179</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Environmental and genetic risk factors in Parkinson's disease: A case–control study in southern italy</title>
<author><name sortKey="De Michele, G" sort="De Michele, G" uniqKey="De Michele G" first="G." last="De Michele">G. De Michele</name>
<affiliation><wicri:noCountry code="subField">Naples</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Filla, A" sort="Filla, A" uniqKey="Filla A" first="A." last="Filla">A. Filla</name>
<affiliation><wicri:noCountry code="subField">Naples</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Volpe, G" sort="Volpe, G" uniqKey="Volpe G" first="G." last="Volpe">G. Volpe</name>
<affiliation><wicri:noCountry code="subField">Naples</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="De Marco, V" sort="De Marco, V" uniqKey="De Marco V" first="V." last="De Marco">V. De Marco</name>
<affiliation><wicri:noCountry code="subField">Naples</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gogliettino, A" sort="Gogliettino, A" uniqKey="Gogliettino A" first="A." last="Gogliettino">A. Gogliettino</name>
<affiliation><wicri:noCountry code="subField">Naples</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ambrosio, G" sort="Ambrosio, G" uniqKey="Ambrosio G" first="G." last="Ambrosio">G. Ambrosio</name>
<affiliation><wicri:noCountry code="subField">Naples</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Marconi, R" sort="Marconi, R" uniqKey="Marconi R" first="R." last="Marconi">R. Marconi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Sanatrix Neurological Institute, Pozzilli (IS)</wicri:regionArea>
<wicri:noRegion>Pozzilli (IS)</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Castellano, A E" sort="Castellano, A E" uniqKey="Castellano A" first="A. E." last="Castellano">A. E. Castellano</name>
<affiliation wicri:level="1"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Sanatrix Neurological Institute, Pozzilli (IS)</wicri:regionArea>
<wicri:noRegion>Pozzilli (IS)</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Campanella" sort="Campanella" uniqKey="Campanella" last="Campanella">Campanella</name>
<affiliation><wicri:noCountry code="subField">Naples</wicri:noCountry>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="1996-01">1996-01</date>
<biblScope unit="volume">11</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="17">17</biblScope>
<biblScope unit="page" to="23">23</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">F7568060A721FF11CB5A29DD33B94F440BE1CB16</idno>
<idno type="DOI">10.1002/mds.870110105</idno>
<idno type="ArticleID">MDS870110105</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Environmental risk factors</term>
<term>Essential tremor</term>
<term>Genetic risk factors</term>
<term>Parkinson's disease</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">To clarify the role of heredity and of some environmental risk factors in the etiology of idopathic Parkinson's disease, we performed a case‐control study in two regions of southern Italy, Campania and Molise. We selected two controls for each parkinsonian patient, the patient's spouse and a sex‐ and age‐matched neurological control. One hundred sixteen consecutive outpatients with Parkinson's disease (77 men, 39 women; mean age ± SD = 62.5 ± 9.9) and the same number of spouses and neurological controls were interviewed about five environmental risk factors (cigarette smoking, well‐water drinking, head trauma with loss of consciousness, strict diets, general anesthesia) and two genetic risk factors (family history of Parkinson's disease or of essential tremor). Well‐water drinking and family history of Parkinson's disease or essential tremor showed a positive association with Parkinson's disease; smoking showed a negative association. The most relevant risk factor was history of familial Parkinson's disease (odds ratio = 14.6; 95% confidence interval = 7.2 − 29.6); 33% of our patients had at least one affected relative. We also showed a unilateral distribution of ancestral secondary cases on the paternal or on the maternal side, which suggests a dominant inheritance. Clinical and epidemiologic features of cases with familial Parkinson's disease showed no peculiarity. The study suggests a strong role of the genetic factors in the etiology of Parkinson's disease.</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
</country>
</list>
<tree><noCountry><name sortKey="Ambrosio, G" sort="Ambrosio, G" uniqKey="Ambrosio G" first="G." last="Ambrosio">G. Ambrosio</name>
<name sortKey="Campanella" sort="Campanella" uniqKey="Campanella" last="Campanella">Campanella</name>
<name sortKey="De Marco, V" sort="De Marco, V" uniqKey="De Marco V" first="V." last="De Marco">V. De Marco</name>
<name sortKey="De Michele, G" sort="De Michele, G" uniqKey="De Michele G" first="G." last="De Michele">G. De Michele</name>
<name sortKey="Filla, A" sort="Filla, A" uniqKey="Filla A" first="A." last="Filla">A. Filla</name>
<name sortKey="Gogliettino, A" sort="Gogliettino, A" uniqKey="Gogliettino A" first="A." last="Gogliettino">A. Gogliettino</name>
<name sortKey="Volpe, G" sort="Volpe, G" uniqKey="Volpe G" first="G." last="Volpe">G. Volpe</name>
</noCountry>
<country name="Italie"><noRegion><name sortKey="Marconi, R" sort="Marconi, R" uniqKey="Marconi R" first="R." last="Marconi">R. Marconi</name>
</noRegion>
<name sortKey="Castellano, A E" sort="Castellano, A E" uniqKey="Castellano A" first="A. E." last="Castellano">A. E. Castellano</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002179 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002179 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:F7568060A721FF11CB5A29DD33B94F440BE1CB16 |texte= Environmental and genetic risk factors in Parkinson's disease: A case–control study in southern italy }}
This area was generated with Dilib version V0.6.23. |